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KMID : 1098420210290060388
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Korean Journal of Medicinal Crop Science
2021 Volume.29 No. 6 p.388 ~ p.397
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Acetylcholinesterase Inhibition and Neuroprotective Effect of Ginseng Root Steam Treatment Containing Low Molecular Weight Ginsenosides
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Kim Chul-Joong
Jeon Ji-Hyeong
Seong Eun-Soo
Choi Seon-Kang
Lim Jung-Dae
Yu Chang-Yeon
Lee Jae-Geun
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Abstract
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Background: Ginsenosides are known to have anti-cancer, anti-inflammatory, and antioxidant effects. Additionally, they are known to improve cognitive ability and memory, and prevent dementia. In this study, the physiological activity of cultured wild ginseng adventitious root (ginseng root, GS) containing low molecular weight ginsenosides was investigated in vitro.
Methods and Results: This experiment was conducted to confirm the acetylcolinesterase (AChE) inhibitory activity, neuroprotectivie effect, and antioxidant effect of GS steam treatment. Through the steaming process, a GS steam treatment containing low molecular weight ginsenosides was prepared and evaluated. The results showed that AChE inhibitory activity, neuroprotective effect, reactive oxygen species (ROS) inhibitory effect, and catalase (CAT) activity effect by H2O2 were concentration-dependent in the group treated with GS steam treatment compared to those in the control group.
Conclusions: In this study, it was demonstrated that the GS steam treatment influenced the AChE inhibitory activity, the neuroprotective effect, and the oxidative stress protective effect of GS.
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KEYWORD
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Panax ginseng C. A. Meyer, Acetylcholinesterase, Alzheimer's Disease, Cell Viability, Cultured Wild Ginseng Adventitious Root, Low Molecular Weight Ginsenosides, Oxidative Stress, Neuroprotective
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